Nursing education has undergone a series of changes along with social changes, fiercer global competence, and educational reform in terms of quality. Changes in the consciousness of patients and conditions of disease require nurses to play more extensive roles and become experts with a wider range of knowledge and skills, better understanding of humans, and more extensive self-regulation than ever before. To keep up with changes in human history as such, Ajou University College of Nursing launched the four-year baccalaureate nursing program and RN-BSN program in 1998. In 2003, a program leading to a Master of Science degree in health education in Ajou University Graduate School was initiated. The master's programs for advanced practice nurses were established in 2004, which focus on educating advanced practice nurses with professional knowledge in their clinical fields. And the Department of Nursing in College of Medicine, Ajou University was promoted to a separate and independent college in 2006.

Nursing science is an academic discipline that scientifically define human relationships with environment, health, and nursing and protect them in a creative way. The philosophy of the college of nursing is based on three virtues which are guiding the principles of Ajou University: "Respect for Human", "Seeking Truth from Fact", and "One World, One Family". The goals of education of the Ajou College of Nursing are as follows:

First, nurses with love for humans
Second, nurses with competence
Third, nurses with the global mind-set