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교수정보의 상세 화면
연구실 :
약학관 209호

연구실번호 :

이메일 :

연구관심분야 :
Develop therapeutic targets of dementia, cardiovascular disease and sleep disorder

홈페이지 :
1996.02 성균관대학교 박사
1988.02 서울대학교 석사
1986.02 서울대학교 학사
경력 - 1988.2 - 1996.2  Researcher, Korea Research Institute of Chemical Technology (KRICT)
- 1996.3 - 2000.2  Research fellow, Dept. Physiology, Ajou Univ. School of Medicine
- 2000.3 - 2011.4  Professor, Associate Prof., Assistant Prof., Ajou Univ. School of Medicine
- 2011.5 - Present  Professor, Ajou Univ. College of Pharmacy
- 1989.1 - 1989.5  Research fellow, Hoechst AG, Germany, Oral Robert’s University, USA
- 2006.7 - 2007.7  Visiting professor, Department of Molecular and Integrative Physiology, University of Illinois, Urbana-Champaign
연구분야 Cardiovascular and cerebrovascular disease, which is induced by blood clot or inflammation, are the leading cause of deaths in the world and lead to various ischemic disease such as myocardial infarction, heart failure, and stroke. Despite of the substantial efforts for the development of therapeutics, few agents have been reached clinical trial. Therefore, the study in this lab has been focused on the development of novel therapeutics from small molecules, natural products and functional foods for cardiovascular, cerebrovascular diseases and various inflammatory diseases. We are using not only in vitro cell culture models (cardiomyocytes, neurons, vascular cells, skin cells. etc) for molecular signaling study, but also in vivo animal models of various diseases (myocardial infarction, heart failure, artherosclerosis, stroke, asthma, atopy) for functional validation study. 
기타 ■  AWARDS
 - 2012. 10. 19 Korea Ministry of Food and Drug Safety award
 - 2013. 11. 10 Seoul National University, College of Pharmacy award
 - 2014. 10. 23 Archives of Pharmacal Research journal development award
 - 2014. 10. 31 Biomolecules & Therapeutics publication award
 - 2015. 08. 30 Ajou University publication award
 - 2017. 02. 25 Ajou University publication award
논문 및 연구활동
  • [논문] Allium cepa extract and quercetin protect neuronal cells from oxidative stress via PKC-e inactivation/ERK1/2 activation (OXIDATIVE MEDICINE AND CELLULAR LONGEVITY) - 2016.09
    정이숙, 이보경
  • [논문] Blockade of Urotensin II Receptor Prevents Vascular Dysfunction (BIOMOLECULES & THERAPEUTICS) - 2016.09
    정이숙, 이병호, 이규양, 김영애, 이동길
  • [논문] Anti-platelet and anti-thrombotic effect of a traditional herbal medicine Kyung-Ok-Ko (JOURNAL OF ETHNOPHARMACOLOGY) - 2016.02
    정이숙, 이경미, 홍남두, 김태호
  • [논문] Fbxo25 controls Tbx5 and Nkx2-5 transcriptional activity to regulate cardiomyocyte development. (BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS) - 2015.02
    정이숙, Hoe-Su Jeong, Eun-shil Jung, Ye-Ji Sim, Su-Jin Kim, Kye-Seong Kim, Ki-Sung Hong, Won-Young Lee, Hyung-Min Chung, Kyung-Tae Park, Chang-Hoon Kim, Jae-Woo Jang
  • [논문] Preventive Effect of Yuzu and Hesperidin on Left Ventricular Remodeling and Dysfunction in Rat Permanent Left Anterior Descending Coronary Artery Occlusion Model (PLoS ONE) - 2015.01
    정이숙, Se Won Park, 유혜연, ji Hun Ahn
  • [논문] Two novel bioactive glucosinolates from Broccoli (Brassica oleracea L. var. italica) florets. (BIOORGANIC & MEDICINAL CHEMISTRY LETTERS) - 2012.09
    박세원, Nazneen Shaik Survay, 양덕천, 장미, 윤두영, 정이숙, Brajesh Kumar
  • [논문] Chrysophanol-8-O-glucoside, an Anthraquinone Derivative in Rhubarb, Has Antiplatelet and Anticoagulant Activities. (JOURNAL OF PHARMACOLOGICAL SCIENCES) - 2012.02
    정이숙, 김영식, 이선미, 서은지, Tran Minh Ngoc
  • [논문] Anti-platelet effects of yuzu extract and its component (FOOD AND CHEMICAL TOXICOLOGY) - 2011.12
    정이숙, 박세원, 정일민, 유혜연
  • [논문] KR-33028, a novel Na+/H+ exchanger-1 inhibitor, attenuates glutamate-induced apoptotic cell death through maintaining mitochondrial function (BIOMOLECULES & THERAPEUTICS) - 2011.10
    정이숙, 유성은, 이규양, 이보경, 이선경
  • [논문] Protective Effect of Components Isolated from Lindera erythrocarpa against Oxidative Stress-induced Apoptosis of H9c2 Cardiomyocytes (Phytotherapy Research) - 2011.03
    김영호, 김정아, 양세영, 이소현, 정이숙, 김미영
  • [논문] Antiplatelet effects of Cyperus rotundus and its component (+)-nootkatone (JOURNAL OF ETHNOPHARMACOLOGY) - 2011.02
    정이숙, 김영식, 곽정환, 이선미, 서은지, 이동욱
  • [논문] Characterization of a cinnamoyl derivative from broccoli (Brassica oleracea L. var. italica) florets (FITOTERAPIA) - 2010.12
    박세원, Survay NS, Kumar B, Upadhyaya CP, 이충환, 최정남, 윤도영, 정이숙, 고은영
  • [논문] Norepinephrine and epinephrine induced distinct badrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes (JOURNAL OF BIOLOGICAL CHEMISTRY) - 2008.01
    Xiang Yang, Wang Yongyu, Gao Xiaoguang, Ramani Biswarathan, 정이숙, Arcangelis Vania De
  • [논문] Pharmacodynamic characteristics and cardioprotective effects of new NHE1 inhibitors (EUROPEAN JOURNAL OF PHARMACOLOGY) - 2007.07
    김경환, 김미영, 김준오, 한원선, 이병호, 이규양, 유성은, 이민구, 정이숙, 남궁완
  • [논문] Anti-hypertensive effect of the Dongchunghacho, Isaria sinclairii, in the spontaneously hypertensive rats (ARCHIVES OF PHARMACAL RESEARCH) - 2007.04
    안미영, 김찬식, 이수환, 문창현, 류강선, 지상덕, 이병무, 정이숙, 조성익
  • [논문] Lysophospatidic Acid Induces Thrombogenic Activity Through PhosphatidyIserine Exposure and Procoagulant Microvesicle Generationin Human Erythrocytes (Arterioscler Thromb Vasc Biol.) - 2007.02
    정진호, 정승민, 이무열, 임경민, 노지윤, 정이숙, 배옥남
  • [논문] Phamacological profile of KR-33028, a highly selective inhibitor of Na(+)/H(+) exchanger (Eur J Pharmacol) - 2006.03
    이병호, 김미영, 이선경, 오광석, 유성은, 이규양, 정이숙, 김미정
  • [논문] Hypoglycemic Effects of Fruits and Vegetables in Hyperglycemic Rats for Prevention of Type-2 Diabetes (원예과학기술지) - 2010.10
    박세원, 이동하, 쉐익나즈닌, 고은영, 홍세진, 장미, 윤도영, 정이숙, 우파드하야
  • [논문] Alkyl thiosulfi(o)nate 화합물의 합성과 생리활성 (JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY(한국응용생명화학회지)) - 2008.09
    경석헌, 경규항, 정이숙, 정현진
  • [학술회의] The effects of Yuzu(yuja) extracts on blood circulation (대한약학회) - 2012.10
    정이숙, 박세원, 김태호
  • [학술회의] The effect of onion extract on platelet aggregation, cell death and inflammation acording to storage periods and condition (대한약학회) - 2012.10
    정이숙, 박세원, 박성례, 이도섭, 현수왕
  • [학술회의] Growth arrest and DNA-damage-inducible 45 β is a target molecule of a protective substance against oxidative stress-induced cardiac cell death (응용약물학회) - 2012.10
    정이숙, 이동하, 김태호, 김영애
  • [학술회의] Protection of ischemia-induced BBB dysfunction by antioxidant nutrient (응용약물학회) - 2012.10
    정이숙, 최현재, 박세원, 현수왕
  • [학술회의] Urotensin II (UII) antagonist attenuates UII-induced endothelial dysfunction. (응용약물학회) - 2012.10
    정이숙, 이병호, 이보경, 박성례
  • [학술회의] Allium cepa attenuates brain edema and BBB dysfunction (World congress of food science and technology ) - 2012.08
    정이숙, 박세원, 장미, 현수왕, 박성례
  • [학술회의] The effects of onion extract on Blood-Brain Barrier (BBB) dysfunction during ischemia/hypoxia (NRF-JSPS Asian Science Seminar) - 2012.02
    정이숙, 박성례, 김태호, 현수왕
  • [학술회의] Anti-platelet activity of yuzu and its components is mediated by inhibition of TXA2 production (2011 Annual meeting of the American society for cell biology) - 2011.12
    정이숙, 박세원, 정일민, 유혜연
  • [학술회의] Phosphorylation of p53 by p38α regulates the expression of gadd45β in cardiomyocytes (2011 Annual meeting of the American society for cell biology) - 2011.12
    정이숙, 김미영, 김재호, 미슈라 싯다르타, 최경숙, 이재혁, 김영애, 유혜연
  • [학술회의] Antiplatelet and antioxidant activities of three green pepper varieties cultivated in korea (Proceedings of the fall international convention of the pharmaceutical society of korea) - 2011.11
    정이숙, 박세원, 현수왕, 유혜연, 김영애
  • [학술회의] Zizyphus jujuba and its active component jujuboside B inhibit the platelet aggregation (Proceedings of the fall international convention of the pharmaceutical society of korea) - 2011.11
    정이숙, 김영식, 이선미, 서은지, 강삼식
  • [학술회의] Cadmium stimulates the expression of ICAM-1 through NF-κB activation regulated by NO in brain microvessel endothelial cells (Experimental Biology) - 2003.08
    정이숙, 백은주, 박은경, 문창규, 김찬식, 문창현, 이수환
  • [학술회의] Protein Kinase C-ε, as a upstream target for mtKATP, is involved in the protective effect of diazoxide against hypoxia-induced cardiac cell death (Experimental Biology 2003) - 2003.08
    정이숙, 김미정, 이수환, 문창현, 백은주
  • [학술회의] Possible role of protein kinase C and mitochondrial KATP in the cardioprotective effect conferred by a novel guanidine derivative, KR-31378 (2002 APS Conference) - 2002.02
    정이숙, 백은주, 유성은, 김민화, 김미영, 문창현, 이수환
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