일반대학원공과대학분자과학기술학과

List

최준원Junwon Choi

  • 소속 분자과학기술학과
  • 연구실혜강관 620호
  • 이메일 junwchoi@ajou.ac.kr
  • 내선번호2449

관심분야

  • 유기화학, 화학생물학, 의약화학, 단백질 당화

학력

  • 2014.09 Massachusetts Inst Tech (MIT) 박사
  • 2008.02 서울대학교 학사

경력

    2020–present	Assistant Professor, Ajou University
2019–2020       Assistant Professor, University of Science and Technology
2017–2020       Senior Research Scientist, Korea Institute of Science and Technology
2015–2017       Postdoctoral Fellow, Stanford University
2015                Visiting Scholar, University of California, Berkeley

연구분야

    Oragnic Reaction Development
Post-Translational Modification (Glycosylation)
Medicinal Chemistry
Chemical Biology

대표논문

  • [논문] 최준원, Lauren J. S. Wagner, Benjamin Schumann, Jase Gehring, Marjoke F. Debets, Megumi Takashima, Melissa A. Gray, Stacy A. Malaker, Suzanne B. P. E. Timmermans, Carolyn R. Bertozzi, Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol.141, No.34, pp. 13442-13453 (8월, 2019)
  • [논문] 최준원, Gregory C. F, Transition Metal-Catalyzed Alkyl–Alkyl Bond Formation: Another Dimension in Cross-Coupling Chemistry, SCIENCE, Vol.356, No.6334, pp. eaaf7230-eaaf7230 (4월, 2017)
  • [논문] Jens Schmidt, 최준원, Albert Tianxiang Liu, Martin Slusarczyk, Gregory C. Fu, A General, Modular Method for the Catalytic Asymmetric Synthesis of Alkylboronate Esters, SCIENCE, Vol.354, No.6317, pp. 1265-1269 (12월, 2016)
  • [논문] 최준원, Pablo Martín-Gago, Gregory C. Fu, Stereoconvergent Arylations and Alkenylations of Unactivated Alkyl Electrophiles: The Catalytic Enantioselective Synthesis of Secondary Sulfonamides and Sulfones, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol.136, No.34, pp. 12161-12165 (8월, 2014)
  • [논문] 최준원, Gregory C. Fu, Catalytic Asymmetric Synthesis of Secondary Nitriles via Stereoconvergent Negishi Arylations and Alkenylations of Racemic α-Bromonitriles, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol.134, No.22, pp. 9102-9105 (5월, 2012)

연구활동

  • [논문] 조영욱, Miso Kang, Do Hee Oh , Duck-Hyung Lee, Hee Jin Jeong , Jae Eun Jung, Junghwan Choi , Nam-Jung Kim, Su Hyun Ji, Sungjoon Kim, Sunyoung Park, Yong-Yea Park, 최준원, Chan Sun Park, Sanghee Lee, Seo-Jung Han, Discovery of Orally Bioavailable Phthalazinone Analogues as an ENPP1 Inhibitor for STING-Mediated Cancer Immunotherapy, JOURNAL OF MEDICINAL CHEMISTRY, Vol.66, pp. 15141-15170 (11월, 2023)
  • [논문] 최준원, Small molecule ectonucleotide pyrophosphatase/phosphodiesterase 1 inhibitors in cancer immunotherapyfor harnessing innate immunity, BULLETIN OF THE KOREAN CHEMICAL SOCIETY, pp. 1-12 (1월, 2023)
  • [논문] 최상기, Jaeseok Lee, 최준원, Adil S. Aslam, Chan Hee Ryu, Hyuk Sang Yoo, Ju Hyun Park, Kang Mun Lee, Sanghee Lee, Woojeong Lim, Young Mee Jung, junsu ko, juyong Lee, 김은하, jongmin Park, N4-phenylquinazoline-4,6-diamine as a tunable fluorescent scaffold for the development of fluorescent probes, DYES AND PIGMENTS, pp. 110987-110987 (1월, 2023)
  • [논문] Kyeongmi Kim, 최준원, Siyeoung Yoon, Soonchul Lee, Effect of the Duration of NSAID Use on COVID-19, Medicina-Lithuania, Vol.58, pp. 1713-1713 (11월, 2022)
  • [논문] Sangbin Jeon, 최준원, Jaiwoo Chung, Jongbeom Oh, Wooyeol Ahn, Soonchul Lee, Finite element analyses of lateralcondyle fracture fixation in paediatrics regarding configuration of Kirschner-wire, BMC MUSCULOSKELETAL DISORDERS, Vol.23, pp. 940-940 (10월, 2022)
  • [논문] Hyun-Ju An, Jae-Hwa Kim, 최준원, Jeongmo Koo, Siyeong Yoon, Soonchul Lee, Genome-Wide Association Study Identifies Genetic VariantsAssociated with Rotator Cuff Tear—A Pilot Study, Diagnostics, pp. 2497-2497 (10월, 2022)
  • [논문] Kyung Rae Ko, Soo-Hong Han, 최준원, Eun-Bee Kwak, Hyun-Ju An, Il-Su Kim, Jusung Lee, Minjung Baek, Sujin Choi, Yunhui Jeong, Soonchul Lee, Substance P Inhibitor Promotes Tendon Healing in a Collagenase-Induced Rat Model of Tendinopathy, AMERICAN JOURNAL OF SPORTS MEDICINE, Vol.50, No.13, pp. 3681-3689 (10월, 2022)
  • [논문] Chi-Hoon Oh, Junhyun Kim, 최준원, Hyun Il Lee, Junhan Kim, Siyeong Yoon, Younghoon Jung, Soo-Hong Han, Soonchul Lee, The Association of Low Skeletal Muscle Mass with Complex Distal Radius Fracture, JOURNAL OF CLINICAL MEDICINE, pp. 5581-5581 (9월, 2022)
  • [논문] 오지선, 최준원, 김세기, 김진만, 안현주, 여현정, 오지수, 최수진, 이순철, Colchicine as a novel drug for the treatment of osteosarcoma through drug repositioning based on an FDA drug library, FRONTIERS IN ONCOLOGY, pp. 893951-893951 (8월, 2022)
  • [논문] Soonchul Lee, Sujin Choi, 최준원, Isaac Kim, Jusung Lee, Young-Hoon Han, Hyun-Ju An, miR-31-3p functions as a tumor suppressor by directly targeting GABBR2 in prostate cancer, FRONTIERS IN ONCOLOGY, pp. 945057-945057 (8월, 2022)
  • [논문] Ki Soo Kim, Kyung-Chae Park , 최준원, Siyeong Yoon, Bo Sung Jung, Simho Jeong, Wooyeol Ahn, Soonchul Lee, Hair methylmercury levels are inversely correlated with arterial stiffness, ATHEROSCLEROSIS, pp. 14-19 (8월, 2022)
  • [논문] 김지호, Hee jin Jeong, Hyo Jae Yoon, Jae Kyun Lee, 최준원, Seo-Jung Han, Synthesis of Benzoxaphosphole 1‑Oxide Heterocycles via a Three-Component Coupling Reaction Involving Arynes, Phosphites, and Ketones, ORGANIC LETTERS, Vol.24, No.11, pp. 2192-2196 (3월, 2022)
  • [논문] Arun Velladurai, 김욱, 김형모, 최상기, 최홍서, 한지혜, 김은하, 최준원, 김종훈, Harnessing aggregation-induced emission property of indolizine derivative as a fluorogenic bioprobe for endoplasmic reticulum, DYES AND PIGMENTS, pp. 110118-110125 (1월, 2022)
  • [논문] 김현기, 이성민, 김은수, 민준식, 최준원, 김은하, 고정길, Fluorescent sensor array for high-precision pH classification with machine learning-supported mobile devices, DYES AND PIGMENTS, pp. 127780-127780 (9월, 2021)
  • [논문] Andrea Marchesi, Beatriz Calle, Ganka Bineva-Todd, 최준원, Helen Flynn, Chloe Roustan, M. Carmen Galan, Mattia Ghirardello, Omur Y. Tastan, Stacy A. Malaker, Benjamin Schumann, Benefits of Chemical Sugar Modifications Introduced by Click Chemistry for Glycoproteomic Analyses, JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol.32, No.9, pp. 2366-2375 (4월, 2021)
  • [논문] Anna Cioce, Ganka Bineva-Todd, 최준원, Anthony J. Agbay, Carolyn R. Bertozzi, Chloe Roustan, Holly L. Douglas, Jacob T. Bush, Marjoke F. Debets, Omur Y. Tastan, Svend Kjaer, Thomas M. Wood, William M. Browne, Benjamin Schumann, Optimization of Metabolic Oligosaccharide Engineering with Ac4GalNAlk and Ac4GlcNAlk by an Engineered Pyrophosphorylase, ACS CHEMICAL BIOLOGY, Vol.16, No.10, pp. 1961-1967 (4월, 2021)
  • [논문] Marjoke F. Debets, Omur Y. Tastan, 최준원, Ambrosius P. Snijders, Anna Cioce, Anthony J. Agbay, Aristotelis Antonopoulos, Carolyn R. Bertozzi, Chloe Roustan, David C. Briggs, Gaelen T. Hess, Ganka Bineva-Todd, Helen Flynn, Holly L. Douglas, Lauren J. S. Wagnere, Leonhard K. R. Moeckl, Michael C. Bassik, Nikolaos Angelis, Simon P. Wisnovsky, Stacy A. Malaker, Stuart M. Haslam, Svend Kjaer, Vivian S. W. Li, W. E. Moerner, William M. Browne, Zhen Li, Benjamin Schumann, Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.117, No.41, pp. 25293-25301 (10월, 2020)
  • [논문] 최준원, Anthony J. Agbay, Daniel Fernandez, Douglas M. Fox, Jennifer J. Kohler, Jessie Peh, Kayvon Pedram, Lauren J. S. Wagner, Liang Lin, Marjoke F. Debets, Melissa A. Gray, Milan Mrksich, Simon P. Wisnovsky, Stacy Alyse Malaker, Zhen Li, Benjamin Schumann, Carolyn R. Bertozzi, Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells, MOLECULAR CELL, Vol.78, No.5, pp. 824-834 (6월, 2020)
  • [논문] Ji Ho Ryu, Min Young Ha, 최준원, Eugene N. Cho, Won Bo Lee, YongJoo Kim, Phase Behavior of Disk-Coil Block Copolymers under Cylindrical Confinement: Curvature-Induced Structural Frustrations, PHYSICAL REVIEW E, Vol.100, No.5, pp. 052502-1-052502-7 (11월, 2019)
  • [논문] 최준원, 정근홍, Theoretical Study on the Toxicity of ‘Novichok’ Agent Candidates, Royal Society Open Science, Vol.6, No.8, pp. 190414-190414 (8월, 2019)
  • [논문] 최준원, Lauren J. S. Wagner, Benjamin Schumann, Jase Gehring, Marjoke F. Debets, Megumi Takashima, Melissa A. Gray, Stacy A. Malaker, Suzanne B. P. E. Timmermans, Carolyn R. Bertozzi, Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol.141, No.34, pp. 13442-13453 (8월, 2019)
  • [논문] 최준원, Gregory C. F, Transition Metal-Catalyzed Alkyl–Alkyl Bond Formation: Another Dimension in Cross-Coupling Chemistry, SCIENCE, Vol.356, No.6334, pp. eaaf7230-eaaf7230 (4월, 2017)
  • [논문] Jens Schmidt, 최준원, Albert Tianxiang Liu, Martin Slusarczyk, Gregory C. Fu, A General, Modular Method for the Catalytic Asymmetric Synthesis of Alkylboronate Esters, SCIENCE, Vol.354, No.6317, pp. 1265-1269 (12월, 2016)
  • [논문] Huan Cong, Zhiwei Zuo, 최준원, Wei Li, David W. C. MacMillan, Gregory C. Fu, Enantioselective Decarboxylative Arylation of α-Amino Acids via the Merger of Photoredox and Nickel Catalysis, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol.138, No.6, pp. 1832-1835 (2월, 2016)
  • [논문] 최준원, Pablo Martín-Gago, Gregory C. Fu, Stereoconvergent Arylations and Alkenylations of Unactivated Alkyl Electrophiles: The Catalytic Enantioselective Synthesis of Secondary Sulfonamides and Sulfones, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol.136, No.34, pp. 12161-12165 (8월, 2014)
  • [논문] Daniel T. Ziegler, 최준원, Alex C. Bissember, José María Muñoz-Molina, Gregory C. Fu, Jonas C. Peters, A Versatile Approach to Ullmann C−N Couplings at Room Temperature: New Families of Nucleophiles and Electrophiles for Photoinduced, Copper-Catalyzed Processes, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol.135, No.35, pp. 13107-13112 (8월, 2013)
  • [논문] 최준원, Gregory C. Fu, Catalytic Asymmetric Synthesis of Secondary Nitriles via Stereoconvergent Negishi Arylations and Alkenylations of Racemic α-Bromonitriles, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol.134, No.22, pp. 9102-9105 (5월, 2012)
해당 데이터는 존재하지 않습니다.
해당 데이터는 존재하지 않습니다.
해당 데이터는 존재하지 않습니다.
해당 데이터는 존재하지 않습니다.

특허 및 기타

  • [특허] 최준원, 골 분화 유도 가능한 신규 화합물, 특허, (출원) (10-2023-0064583) (5월, 2023)