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Scientists identify a novel orally active small-molecule tumor necrosis factor inhibitor that suppressed symptoms of inflammatory arthritis in mice Autoimmune diseases such as rheumatoid arthritis are known to be associated with tumor necrosis factor (TNF), a proinflammatory cytokine. While these conditions are known to have a profound impact on the lives of patients, researchers from Korea have identified a small-molecule called TNF-inhibitory molecule 1 (TIM1), which can inhibit excessive signaling by TNF, lower arthritis-related inflammation, and ultimately improve patients’ quality of life. Scientists from Korea have identified TIM1c, an orally active small-molecule inhibitor, which inhibits excessive signaling by the proinflammatory cytokine tumor necrosis factor, paving the way for effective treatment of autoimmune diseases, including rheumatoid arthritis.Image courtesy: peterschreiber.media from Shutterstock Millions of people across the world suffer from chronic pain and disability that arises from autoimmune diseases like rheumatoid arthritis (RA), which reduces their overall quality of life. The proinflammatory cytokine tumor necrosis factor (TNF)—a type of protein secreted by specialized cells in the immune system—is known to play a major role in conditions such as RA. While TNF provides protection against tumors and pathogens, its dysregulation or regular excessive production has been associated with an array of pathological conditions such as inflammatory bowel disease, RA, Alzheimer’s disease, and even cancer. Over the years, scientists have developed several drugs that can bind to and inhibit the excessive production of the signaling protein TNF. However, while these therapeutics have shown clinical success, they are often quite expensive and not available in the form of easy-to-use oral medications. Motivated by the need for improving the lives of patients by developing innovative treatments, a team of researchers, led by Professor Sangdun Choi from Ajou University, has identified a new orally active small-molecule, named TNF-inhibitory molecule 1c (TIM1c). Their study was published in Volume 15, Issue 759 of the journal Science Signaling on 8 November 2022. First, the team utilized a ligand-based and combined structure-based virtual screening method to identify the starting lead compound. They idenfitied TIM1, which inhibited TNF-induced death of human and mouse cells, and further investigated its mechanism of action. “Unraveling the molecular mechanisms of disease pathways, cellular receptors, and their connection to TNF signaling can provide the necessary information needed for the development of less cytotoxic and more potent small-molecule inhibitors of TNF than the commercially available ones,” explains Prof. Choi, while elaborating about this study. A series of experiments revealed that TIM1 inhibited the secretion of inflammation-triggering cytokines IL-6 and IL-8 by disrupting the formation of a functional TNF homotrimer—a stable and biologically active form of TNF. It thus prevented the protein from attaching to its receptors found on cell membranes, inhibiting the TNF signaling pathway. The team also found that in the mouse model, TIM1c, a more potent variant of TIM1, was not only bioavailable on oral administration, but also reduced overall arthritis index and paw swelling and improved joint pathology. The immunological effects of orally administered TIM1c were similar to those of the FDA-approved TNF-targeting biologic drug etanercept, which acts as a TNF receptor decoy, in mice. The promising small-molecule therapy TIM1c and the insights into its working mechanism have opened new avenues for the development of effective therapeutics for TNF-mediated inflammatory diseases. “We believe that our research could enhance treatment adherence, reduce healthcare costs, and ultimately improve the quality of life by providing patient-friendly oral alternatives to traditional injectable biologics,” concludes Prof. Choi. Here’s hoping that these findings improve the life of patients suffering from chronic and debilitating autoimmune conditions! ReferenceAuthors:Nasir Javaid1, Mahesh Chandra Patra1, Da-Eun Cho2, Maria Batool1,3, Yoongeun Kim2, Gwang Muk Choi2, Moon Suk Kim1, Dae-Hyun Hahm2,4,*, and Sangdun Choi1,3,*Title of original paper:An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in miceJournal:Science Signaling DOI:10.1126/scisignal.abi8713 Affiliations:1Department of Molecular Science and Technology, Ajou University 2Department of Biomedical Sciences, Graduate School, Kyung Hee University3S&K Therapeutics, Ajou University Campus Plaza4Department of Physiology, College of Medicine, Kyung Hee University*Corresponding authors’ email id’s: dhhahm@khu.ac.kr (D.-H.H.); sangdunchoi@ajou.ac.kr (S.C.)About Ajou UniversityFounded in 1973, Ajou University has quickly grown to become one of the top universities in the Republic of Korea. With over 15,000 students and 50 research centers in diverse fields, Ajou University partakes in the largest national research and graduate education project funded by the Korean Ministry of Education. In line with its recently reformed vision, Ajou University’s goal is to change society by connecting minds and carrying out high-impact research to improve the welfare of people in and outside Korea. Website: https://www.ajou.ac.kr/en/index.do About Dr. Sangdun ChoiSangdun Choi is a distinguished scientist known for his contributions to Toll-like receptor (TLR) biology and autoimmune disease research. Currently, he is a Professor at the Department of Molecular Science and Technology, Ajou University. With over 200 published papers and several patents to his name, he has made significant strides in the development of small-molecule therapeutics targeting TNF signaling. Dr. Choi's groundbreaking work has earned him numerous accolades in the field of immunology, and his editorial roles in reputable research journals reflect his leadership in advancing scientific knowledge. He is also the editor of two editions of the 'Encyclopedia of Signaling Molecules,' showcasing his expertise in molecular signaling pathways.
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- 작성자오동우
- 작성일2023-09-20
- 1425
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Researchers investigate the potential of self-assembled hyaluronic acid nanoparticles for treating inflammatory skin diseasesConventional topical approaches to treat psoriasis have a variety of side effects. To address these limitations, researchers from Korea, investigated the potential of self-assembled hyaluronic acid nanoparticles in mouse models and found that they can effectively treat psoriasis without overt side effects, and can also pave the way for powerful and safe nanomedicine platforms for other chronic inflammatory diseases. Image source: Reprinted (adapted) with permission from ACS Nano 2022, 16,12, 20057-20074. Copyright 2022 American Chemical Society Caption: Hyaluronic acid nanoparticles show potential for effective treatment of psoriasis, without overt side effects and can also pave the way for a powerful nano-medicine platform for a variety of inflammatory diseases.Psoriasis is a chronic skin condition characterized by itchy and painful skin patches. It occurs when the body’s immune system mistakenly attacks its own healthy skin. Conventional psoriasis treatments (oral medications) primarily aim to alleviate symptoms by limiting inflammatory responses. Topical therapy, applied directly on the skin, on the contrary, offers a more favorable non-invasive and safer option. However, its long-term use and high dosage may cause a variety of side effects.To address these limitations, a team of researchers from Korea, led by Professor Wook Kim and Dr. Eunha Kim from Ajou University investigated the potential of self-assembled hyaluronic acid nanoparticles (HA-NPs) for treating psoriasis. Their study was published in Volume 16, Issue 12 of the journal ACS Nano on 14 November, 2022. “HA-NPs have previously served as biocompatible and safe drug delivery carriers due to their unique chemical and biological properties. They can exert their own therapeutic effects while maintaining their role as drug carriers,” explains Prof. Kim.The researchers conducted a series of experiments to assess the impact of HA-NPs on mice with psoriasis-like skin dermatitis induced by imiquimod (IMQ) and interleukin-23 (IL-23). They found that HA-NPs could penetrate IMQ-inflamed skin and target specialized immune cells called ‘macrophages’ through immune receptors called TLR4. They were able to suppress the activation of macrophages associated with worsening psoriasis. The results showed that HA-NPs reduced skin inflammation caused by IMQ and IL-23, while restoring the compromised skin barrier and alleviating psoriasis-like skin dermatitis. Notably, the researchers discovered that the outermost layer (shell) of HA-NPs was critical to its efficacy, which was comparable to other conventional psoriasis therapeutics commonly used in clinical settings. Highlighting the impact of their study, Dr. Kim says “HA-NPs could provide a potent nano-medicine platform capable of working at low dosages with minimal side effect, exerting synergistic effects against psoriasis and other inflammatory diseases”. However, the researchers acknowledge that further validation is required because these experiments were conducted on mice and may not accurately reflect the conditions of a human body.Nonetheless, novel psoriasis treatments such as this one may help to reduce the social distress caused by exclusion, discrimination, and stigma that people with psoriasis and other skin disorders face on a regular basis.ReferenceAuthors:1Wang Hee Lee, 1Jun Gi Rho, 1Yeyoung Yang, 1Seulbi Lee, 1Sohui Kweon, 2Hyung-Mo Kim, 1Juhwan Yoon, 1Hongseo Choi, 1Eunyoung Lee, 1Su Ha Kim, 1Sohee You, 1Yujin Song, 3Young Soo Oh, 4Hwan Kim, 5,10Hwa Seung Han, 1Ji Hye Han, 6Myeongwoo Jung, 2Young Hwan Park, 1Yang Seon Choi, 6Sukyoung Han, 7Junho Lee, 1Sangdun Choi, 8Jung-Woong Kim, 9, 11Jae Hyung Park, 6Eun Kyung Lee, 3Woo Keun Song, 1Eunha Kim* and 1Wook Kim*Title of original paper:Hyaluronic Acid Nanoparticles as a TopicalAgent for Treating PsoriasisJournal:ACS NanoDOI:https://doi.org/10.1021/acsnano.2c07843 Affiliations1Department of Molecular Science & Technology, Ajou University, Korea2KIURI Research Center, Ajou University, Korea3Cell Logistics Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Korea4GIST Central Research Facilities, Bio Imaging Laboratory, Gwangju Institute of Science and Technology, Korea5School of Chemical Engineering, College of Engineering, Sungkyunkwan University, Korea6Department of Biochemistry, College of Medicine, The Catholic University of Korea, Korea7Pharmaceutical Institute, FromBIO, Suwon, Korea8Department of Life Science, Chung-Ang University, Korea9School of Chemical Engineering, Sungkyunkwan University, Korea10Natural Product Informatics Research Center, Korea Institute of Science and Technology (KIST),11College of Engineering and Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Korea*Corresponding author’s email: wookkim21@ajou.ac.kr; ehkim01@ajou.ac.krAbout Ajou UniversityFounded in 1973, Ajou University has quickly grown to become one of the top universities in the Republic of Korea. With over 15,000 students and 50 research centers in diverse fields, Ajou University partakes in the largest national research and graduate education project funded by the Korean Ministry of Education. In line with its recently reformed vision, Ajou University’s goal is to change society by connecting minds and carrying out high-impact research to improve the welfare of people in and outside Korea. Website: https://www.ajou.ac.kr/en/index.doAbout Professor Wook KimProfessor Wook Kim is a full-time Professor at the Department of Molecular Science and Technology at Ajou University, Republic of Korea. He received his Ph.D. in Molecular Cell Biology from Gwangju Institute of Science and Technology (GIST) in 2006 under the guidance of Prof. Woo Keun Song. Before coming to Ajou University, he completed his postdoctoral training at the National Institute of Health (NIH), USA. His main research interests are identifying the pathogenesis of chronic inflammatory diseases and developing therapeutic agents to treat these diseases.About Dr. Eunha KimDr. Eunha Kim is an Associate Professor of Department of Molecular Science and Technology at Ajou University. He received his Ph.D. from the Department of Chemistry at Seoul National University in 2011 under guidance of Prof. Seung Bum Park. After postdoctoral work at Harvard Medical School guidance with Prof. Ralph Weissleder, he began his academic career in 2015 in the Department of Molecular Science and Technology at Ajou University in Suwon. His research integrates chemistry and biology to illuminate biology and enable next-generation diagnostic tools and therapeutics.
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- 작성자국제교류팀
- 작성일2023-09-15
- 3735
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Researchers have developed a novel electroactive wrinkled nanomembrane electrode-based hydrogel actuator for untethered insect-sized aquabotsHydrogel-based actuators for soft robots suffer from slow response speed and poor controllability. To address these limitations, a team of researchers from Korea has now developed a new wrinkled nanomembrane electrode-based hydrogel actuator with high energy efficiency and power density. This technology can be used for developing active medical devices and insect-scale aquabots that can be operated in humanly inaccessible environments. A novel hydrogel actuator based on wrinkled nanomembrane electrodes can address the intrinsic limitations of hydrogel actuators, enabling the development of untethered soft robots and active medical devices.Image courtesy: Ministry of Science and ICT, KoreaDespite the rapid advancements in microprocessors, energy storage, and electromechanical actuators, the fundamental drawbacks of conventional electric motors using bulky and rigid components have limited the development of insect-scale soft robots. To resolve these issues, research efforts have focused on hydrogel-based soft actuators which allow diverse chemical modifications and high mechanical deformation. However, these actuators suffer from slow response speed and poor controllability owing to technical challenges in producing electrodes on the hydrogels.In a new study, a team of researchers from Korea, led jointly by Associate Professor Je-Sung Koh from the Department of Mechanical Engineering at Ajou University and Professor Jinhan Cho from the Department of Chemical and Biological Engineering at Korea University, has developed a new electroactive hydrogel actuator based on wrinkled nanomembrane electrodes (WNEs) driven by electroosmosis. In this process, an electric charge is applied to the hydrogel to speed up and regulate the movement of water inside it, thereby facilitating the controlled swelling of the hydrogel. Their study was published in the journal Science Robotics on 26 October 2022.The hydrogel actuator was created using capillary-assisted in situ assembly of metal nanoparticles. This method resulted in the formation of a WNE layer on the hydrogel's surface, offering a large surface area and a porous structure. Importantly, it exhibited high electrical conductivity and mechanical deformability, enabling the hydrogel to stretch up to 110% of its original size.These features enabled the WNE-coated hydrogel to exhibit outstanding actuation performance while operating at a voltages less than 3 V. It achieved a strain of over 50%, an energy density exceeding 700 kilojoules per cubic meter, and a power density surpassing 30 kilowatts per cubic meter. These remarkable characteristics allowed the researchers to develop an insect-scale autonomous aquabot with an onboard control unit and power source that occupied only 2% of its total mass. As a result, the robot achieved high locomotive speed and could move untethered independently.Dr. Koh highlights the practical importance of their study: “Considering the low-power requirements and the ability to miniaturize soft actuators, this technology could find application in exploration robots that operate in diverse environments inaccessible to humans.” Additionally, it has the potential to be utilized in active medical devices that can be attached to or implanted within the human body. “This technology can enable the development of soft autonomous robots and biomimetic insects. Furthermore, the fundamental technology of hydrogel electrode fabrication can easily transform functional hydrogels into electronic materials, and can thus be applied to various types of next-generation devices,” concludes an optimistic Dr. Koh.ReferenceAuthors:Jongkuk Ko1, Changhwan Kim2, Dongjin Kim2, Yongkwon Song1, Seokmin Lee1, Bongjun Yeom3, June Huh1,4, Seungyong Han2, Daeshik Kang2, Je-Sung Koh2,*, Jinhan Cho1,5,*Title of original paper:High-performance electrified hydrogel actuators based on wrinkled nanomembrane electrodes for untetheredinsect-scale soft aquabotsJournal:Science RoboticsDOI:10.1126/scirobotics.abo6463Affiliations:1Department of Chemical and Biological Engineering, Korea University2Department of Mechanical Engineering, Ajou University3Department of Chemical Engineering, Hanyang University4Department of Life Sciences, Korea University5KU-KIST Graduate School of Converging Science and Technology, Korea University*Corresponding authors’ emails: jinhan71@korea.ac.kr (Jinhan Cho); jskoh@ajou.ac.kr (Je-Sung Koh)About Ajou UniversityFounded in 1973, Ajou University has quickly grown to become one of the top universities in the Republic of Korea. With over 15,000 students and 50 research centers in diverse fields, Ajou University partakes in the largest national research and graduate education project funded by the Korean Ministry of Education. In line with its recently reformed vision, Ajou University’s goal is to change society by connecting minds and carrying out high-impact research to improve the welfare of people in and outside Korea. Website: https://www.ajou.ac.kr/en/index.doAbout the authorJe-Sung Koh is an Associate Professor at the Department of Mechanical Engineering at Ajou University in Korea. His research group is developing biologically-inspired robotic technologies. This includes abstracting principles from nature’s creatures and building robots using smart materials. His research interests encompass design and fabrication with smart materials, robots based on foldable structures, and soft robotics for enabling human-robot interaction.
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- 작성자국제교류팀
- 작성일2023-07-27
- 1480
- 동영상동영상
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Researchers propose a novel technique for selectively and rapidly modulating the threshold voltage of indium–gallium–zinc oxide thin-film transistorsIndium–gallium–zinc oxide (IGZO) semiconductors are promising as active components in thin-film transistors owing to their favorable electrical and optical properties. However, uncontrolled oxygen vacancies in IGZO can degrade device performance through negative shifts in the transistor threshold voltage (Vth), which should ideally be close to zero. Now, researchers from Korea realize a rapid modulation of Vth using UV irradiation, opening doors to reliable oxide devices with high mobility and large-area transparency.Caption: Selective modulation of the threshold voltage (Vth) in indium–gallium–zinc oxide semiconductor-based thin-film transistors with UV/ozone treatment of the substrate. Amorphous indium–gallium–zinc oxide (IGZO) semiconductors are an essential component in the fabrication of next-generation unconventional electronic devices and have been considered as active components in thin-film transistors (TFTs), thanks to their electrical and optical performances. Moreover, they allow for high-throughput production via sol–gel process.In TFTs, an important scaling factor for device performance is the threshold voltage (Vth). Ideally, a Vth close to 0 V is desirable for accurate and stable operation. However, in IGZO-based TFTs, a major problem arises from uncontrolled oxygen vacancies in the IGZO layer, which results in negative shifts in Vth. This, in turn, leads to unstable and poor device performance. While several methods have been adopted for controlling these vacancies, it is still challenging to adjust Vth quickly at room temperature since controlling the vacancies require long processing times. To address these issues, a team of researchers from Korea has recently proposed a novel UV/ozone (UVO) treatment of the IGZO layer at room temperature that enables a rapid adjustment of Vth within 3 minutes. “The proposed technology for Vth modulation using UV light can be selectively operated within the substrate area. As a result, we were able to demonstrate IGZO semiconductors with different Vth values by controlling the exposed area,” explains Prof. Sungjun Park from Ajou University, who led the study. In their work published in the journal of Advanced Materials Interfaces, the team used a sol–gel process to fabricate large-area IGZO semiconductors in a cost-effective manner. Then, using the UVO treatment, they showed that they could preserve the Vth close to 0 V under gate bias stress. To understand the mechanism underlying the UVO-based modulation, the team examined the electrical and physicochemical properties of the IGZO TFTs with and without the UVO treatment using transmission line method and X-ray photoelectron spectroscopy. The analysis revealed that the UVO treatment led to both a rapid decline in oxygen vacancies as well as the formation of strong bonding in the IGZO channel without any change in the contact resistance. This, in turn, allowed for a fast Vth modulation with stable device operation.“The Vth modulation by UV irradiation points to the selective performance control of metal oxide sol–gel devices and circuits and highlights their potential as a substitute for silicon semiconductor, ” says Prof. Park. “The performance variation of the IGZO TFTs through UVO irradiation can be used in the latest technologies that require high mobility and transparency, such as displays and optical communication,” he concludes. Indeed, IGZO semiconductors may come to dominate the semiconductor industry soon! ReferenceAuthors:Wonsik Kim1, Won-June Lee2, Taehyun Kwak1, Seokhyeon Baek1, Seung-Hoon Lee3, and Sungjun Park1,*Title of original paper:Influence of UV/Ozone Treatment on Threshold Voltage Modulation in Sol–Gel IGZO Thin-Film TransistorsJournal:Advanced Materials InterfacesDOI:10.1002/admi.202200032Affiliations:1Department of Electrical and Computer Engineering, Ajou University2School of Materials Science and Engineering, Gwangju Institute of Science and Technology3Division of Advanced Materials, Korea Research Institute of Chemical Technology (KRICT) *Corresponding author’s email: sj0223park@ajou.ac.kr About Ajou UniversityFounded in 1973, Ajou University has quickly grown to become one of the top universities in the Republic of Korea. With over 15,000 students and 50 research centers in diverse fields, Ajou University partakes in the largest national research and graduate education project funded by the Korean Ministry of Education. In line with its recently reformed vision, Ajou University’s goal is to change society by connecting minds and carrying out high-impact research to improve the welfare of people in and outside Korea. Website: https://www.ajou.ac.kr/en/index.do About the authorDr. Sungjun Park is an Assistant Professor at the Department of Electrical and Computer Engineering at Ajou University, Korea since 2020. His group studies flexible and stretchable high-performance electronic devices for wearable and bio-medical applications. Before coming to Ajou University, he received his PhD from the School of Materials Science and Engineering at Gwangju Institute of Science and Technology in Korea in 2016. Thereafter, he did his postdoctoral training at RIKEN and remained a visiting researcher at the University of Tokyo, Japan, from 2016 to 2018. Thereafter, he worked as a Senior Researcher in Samsung Advanced Institute of Technology (SAIT) in Korea from 2018 to 2020.
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- 작성자국제협력팀
- 작성일2022-11-15
- 5744
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Researchers develop an alternative to inkjet printing for enhanced intensity and perfect color conversion in organic LED displaysExisting blue organic light emitting diode (BOLED) displays use inkjet printing-based color filters for color conversion, resulting in a trade-off between perfect conversion and brightness. To tackle this, researchers from Korea have now developed luminescent films that are extremely thin compared to inkjet printing, can completely convert colors, and enhance light intensity. The deposited films could potentially be applied to quantum dot-enhanced BOLED displays soon. Credit: Grzegorz Czapski from Shutterstock.Caption: A technique developed by researchers from Korea, called ultrasonic-assisted aerosol deposition, for the direct co-deposition of perovskite quantum dots and metal oxides facilitates perfect color conversion and enhances the luminance of blue OLED displays.In recent times, organic light emitting diodes (OLEDs) have revolutionized the flat-panel display industry. Additionally, with the advent of quantum dot (QD)-enhanced LCDs, it is now possible to achieve a wide range of realistic color experience owing to their narrower emission bandwidth. But, the dependence of these technologies on color filters to produce color subpixels limits their utilization in large-area panel displays. This challenge persists even with the novel QD-OLED hybrid system, which uses an inkjet printing process to print color conversion layers (CCLs). Besides being stringent, the inkjet printing process fails to achieve the optimal thickness and density for QDs and experiences the issue of blue light leakage, impeding the advancement of these display technologies. Now, a team of researchers from Korea report a novel film fabrication method that overcomes these limitations, facilitating perfect color conversion and enhanced light intensity. The study was led by Prof. Sang-Wook Kim of Ajou University, Korea and was published in the Chemical Engineering Journal. As Prof. Kim explains, “We utilized a technique called ‘ultrasonic-assisted aerosol deposition’ (UAD) [A1]to develop thin CCLs and simultaneously used lead halide perovskite nanocrystals as light-emitting material on CCLs, which demonstrated excellent color purity and high luminous efficiency levels.” To this end, the researchers prepared a blue OLED (BOLED) using ITO glass and deposited the synthesized perovskite quantum dot (PeQD) aerosol /metal oxide composite layers on it. The deposited films were a mere 3 μm thick, a quarter of the inkjet-printed films! The PeQD layers embedded with aluminum oxide and silica particles facilitated efficient blocking of blue light leakage. In addition, the metal oxides significantly increased the luminance intensity from the BOLED to the CCL. Further, the researchers demonstrated the compatibility of this novel technique with versatile patterning processes. They showed that UAD can be combined with a fine-metal shadow mask to produce a pattern of 30-μm diameter dots. Particularly, the direct writing method for creating PeQD array patterns provided the narrowest line patterns of about 13 μm. Elaborating the advantage of this method, Prof. Kim notes, “The proposed technique enables the formation of very dense films without the need for any complicated equipment, and requires relatively less throughput time compared to other deposition techniques.” This development can greatly simplify the color patterning process in LED displays, and help achieve high display resolutions, marking an advancement in display printing technology. Going ahead, the “color filter free” method is expected to find usage in QD-enabled displays, ultimately contributing to their application in ultra-large panel displays.ReferenceAuthors:Sunghoon Kim1, Seokwoo Kang2, Seungmin Baek3, Jinouk Song4, Na-Eun Mun1, Hyukmin Kwon2, Hyo-Geun Kwon3, Yong-Jin Pu5, Tae-Woo Lee6, Seunghyup Yoo4, Jong-Min Oh7, Jongwook Park2, Sang-Wook Kim3Title of original paper:Highly thin film with aerosol-deposited perovskite quantum dot/metal oxide composite for perfect color conversion and luminance enhancementJournal:Chemical Engineering JournalDOI:https://doi.org/10.1016/j.cej.2022.135991Affiliations:1 Department of Applied Chemistry Food Science and Technology, Dong-Eui University2 Integrated Engineering, Department of Chemical Engineering, Kyung Hee University3 Nanomaterials Laboratory, Department of Molecular Science and Technology, Ajou University4 School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST) 5 RIKEN Center for Emergent Matter Science (CEMS)6 Department of Materials Science and Engineering, Seoul National University7 Department of Electronic Materials Engineering, Kwangwoon University*Corresponding author’s email: swkim@ajou.ac.krAbout Ajou UniversityFounded in 1973, Ajou University has quickly grown to become one of the top universities in the Republic of Korea. With over 15,000 students and 50 research centers in diverse fields, Ajou University partakes in the largest national research and graduate education project funded by the Korean Ministry of Education. In line with its recently reformed vision, Ajou University’s goal is to change society by connecting minds and carrying out high-impact research to improve the welfare of people in and outside Korea. Website: https://www.ajou.ac.kr/en/index.do About the authorSang-Wook Kim is a Professor at the department of bioengineering and applied chemistry, Ajou University. He received his PhD in applied chemistry from the Seoul National University in 2002. Thereafter, he completed his postdoctoral training from the Bawendi lab at Massachusetts Institute of Technology, USA before joining Ajou University. His research mainly focuses on quantum dot synthesis and application. In the recent past, he has worked on perovskite quantum dots and their LED application. He has published about 150 papers on nanoscience.[A1]We have now added this abbreviation here since it has been used later in the press note.
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- 작성자국제협력팀
- 작성일2022-11-15
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