<기업가정신과 창업> 세미나 안내 드립니다.

♠ 주제 : Site-specific Cross Linker for Homogeneous Antibody-Drug Conjugate (ADC)

♠ 연사 : 정상전 교수님 (성균관대학교 약학대학)

♠ 일시 : 2021년 9월 16일 17:00~18:00 

♠ 초청 : 유태현교수님(내선 3543)

Abstract

Title: Site-specific Cross Linker for Homogeneous Antibody-Drug Conjugate (ADC)

Sang J. Chung

School of Pharmacy, Sungkyunkwan University & AbTis Co. Ltd., Suwon, Korea

Antibody-drug conjugate (ADC) technology represents the most promising platform to accommodate targeted anti-cancers from highly potent cytotoxic agents which generally show serious side effects in human application. Since a cytotoxic drug in ADC is covalently connected to an antibody it is not toxic and its pharmacokinetic property largely depends on the antibody. When ADC internalizes the cytotoxic drug is released from antibody to show the original cytotoxicity. The chemical strategy used in most clinically approved ADCs are based on harnessing the reactivity of Lys and Cys residues on antibody for conjugation leading to heterogenous mixture of ADCs. We have developed novel chemical cross-linkers which specifically acylate Lys248 of native antibodies (human IgG1, IgG2, and IgG4). Using these linkers ADC products have been prepared and tested for anticancer effect in vivo as well as in vitro. In this seminar a brief overview of ADCs and the details of our results will be presented.

♠ 수강방법 : 실시간 ZOOM 

Topic: MST101_ 기업가 정신과 창업(O0090-1) [정상전 교수님]

Time: Sep 16, 2021 05:00 PM Seoul

Join Zoom Meeting

https://ajou-ac-kr.zoom.us/j/89383326955?pwd=aWxSMllOL0x4dXdIK2grN0VucWgzdz09

Meeting ID: 893 8332 6955

Passcode: 807175